1-BROMO-3-CHLORO-5-NITROBENZENE

Base Information

• Chemical Name: 1-BROMO-3-CHLORO-5-NITROBENZENE
• CAS No.: 219817-43-3
• Molecular Formula: C₆H₃BrClNO₂
• Molecular Weight: 236.452
• Hs Code.: 2904909090
• Mol file: 219817-43-3.mol

Synonyms:3-Bromo-5-chloronitrobenzene

Chemical Property of 1-BROMO-3-CHLORO-5-NITROBENZENE

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Melting Point: 81.2 °C
• Refractive Index: 1.619
• Boiling Point: 268.817°C at 760 mmHg
• Flash Point: 116.376°C
• PSA: 45.82000
• Density: 1.827g/cm³
• LogP: 3.53390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-3-chloro-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-3-CHLORO-5-NITROBENZENE

There total 15 articles about 1-BROMO-3-CHLORO-5-NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4-chloro-2-nitro-benzoic acid (6280-88-2) → 1-bromo-3-chloro-5-nitrobenzene (219817-43-3)

Guidance literature:

With copper(I) oxide; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bismuth (III) nitrate pentahydrate; oxygen; sodium bromide; In dimethyl sulfoxide; at 170 ℃; for 10h; regioselective reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.9b00460

Reference yield:

2-chloro-6-bromo-p-nitrobenzenesulfonic acid → 1-bromo-3-chloro-5-nitrobenzene (219817-43-3)

Guidance literature:

With acetic acid; at 20 - 25 ℃; for 0.75h; under 15001.5 - 18751.9 Torr; Temperature; Pressure;

Reference yield:

1-amino-2-bromo-4-nitro-6-chlorobenzene (99-29-6) → 1-bromo-3-chloro-5-nitrobenzene (219817-43-3)

Guidance literature:

upstream raw materials:

2-bromo-4-chloro-6-nitrobenzenamine

1-amino-2-bromo-4-nitro-6-chlorobenzene

3,4-dichloronitrobenzene

2-Chloro-4-nitroaniline

Refernces

• 1、 Li, Xuejing,Deng, Xingwang,Coyne, Anthony G.,Srinivasan, Rajavel. "meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation". . p. 8018 - 8023. Retrieved 2019/05/29.
• 2、 -. "NOVEL AMIDE COMPOUNDS". . . Retrieved 2008/06/13.