N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Base Information

Chemical Name:N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine
CAS No.:223632-84-6
Molecular Formula:C₂₁H₂₃ClFNO₄S
Molecular Weight:439.935
Hs Code.:

Synonyms:N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

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Chemical Property of N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Chemical Property:

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Technology Process of N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

There total 6 articles about N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 98-59-9
p-toluenesulfonyl chloride

: 223632-77-7
N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-hydroxymethylpiperidine

: 223632-84-6
N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1021/jm9806906

Reference yield:

: 21900-30-1
3-chloro-4-methyl-benzoyl chloride

: 223632-84-6
N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

3: dimethylsulfoxide / 3.5 h / 60 °C

4: 48 percent / HF*pyridine / CH₂Cl₂ / a) -10 deg C, 15 min, b) RT, 16 h

5: 78 percent / pyridine / Ambient temperature

With pyridine; formic acid; TEA; pyridine hydrogenfluoride; copper(II) sulfate; In dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm9806906

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 223632-84-6
N-(3-chloro-4-methylbenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

3: dimethylsulfoxide / 3.5 h / 60 °C

4: 48 percent / HF*pyridine / CH₂Cl₂ / a) -10 deg C, 15 min, b) RT, 16 h

5: 78 percent / pyridine / Ambient temperature

With pyridine; formic acid; TEA; pyridine hydrogenfluoride; copper(II) sulfate; In dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm9806906