(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester
CAS No.:161878-70-2
Molecular Formula:C₃₁H₄₈N₂O₉
Molecular Weight:592.73
Hs Code.:

Synonyms:(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

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Chemical Property of (S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

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Technology Process of (S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

There total 2 articles about (S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 161878-70-2
(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70percent aq. perchloric acid / 48 h

2: 1.) isobutyl chloroformate, 4-methylmorpholine, / 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) from -20 deg C to RT

With 4-methyl-morpholine; perchloric acid; isobutyl chloroformate;
DOI:10.1021/jm00046a014

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 581785-29-7
di-tert-butyl L-α-aminoadipate

: 161878-70-2
(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) from -20 deg C to RT;
DOI:10.1021/jm00046a014

Reference yield:

: 161878-70-2
(S)-2-((S)-4-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-hexanedioic acid di-tert-butyl ester

: 161878-85-9
(S)-2-((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-hexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / tetrahydrofuran / 4 h / 760 Torr

2: 73 percent / diethyl cyanophosphoridate, Et₃N / dimethylformamide / 2 h / Ambient temperature

With diethyl cyanophosphoridate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00046a014