tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

Base Information

Chemical Name:tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate
CAS No.:1528459-51-9
Molecular Formula:C₄₀H₅₄N₂O₁₁S₂
Molecular Weight:803.008
Hs Code.:

Synonyms:tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

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Chemical Property of tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

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Technology Process of tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

There total 7 articles about tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 320635-20-9
tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate

: 124243-00-1
4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid

: 1528459-51-9
tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

Guidance literature:: 4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201403965

Reference yield: 82.0%

: tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl) carbamate

: 124243-00-1
4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid

: 1528459-51-9
tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

Guidance literature:: 4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

tert-butyl (3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl) carbamate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c3cc47003b

Reference yield:

: 4246-51-9
4,7,10-trioxa-1,13-diaminotridecane

: 1528459-51-9
tert-butyl (1-oxo-1-{4-[3-tosyl-2-(tosylmethyl)propanoyl]phenyl}-6,9,12-trioxa-2-azapentadecan-15-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc47003b