(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

Base Information

Chemical Name:(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal
CAS No.:1443542-48-0
Molecular Formula:C₂₀H₂₂O₅
Molecular Weight:342.392
Hs Code.:

Synonyms:(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

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Chemical Property of (Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

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Technology Process of (Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

There total 10 articles about (Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1443542-47-9
(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-en-1-ol

: 1443542-48-0
(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1.08333h; Inert atmosphere;
DOI:10.5012/bkcs.2013.34.4.1247

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1443542-48-0
(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: sodium hydride / mineral oil; dimethyl sulfoxide; hexane / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 0.17 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -50 - 0 °C / Inert atmosphere

3.2: 1 h

3.3: 0.5 h / -20 °C

4.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: hydrogen; 10% Pd-CaCO3; quinoline / ethyl acetate / 2 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; quinoline; n-butyllithium; 10% Pd-CaCO3; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; mineral oil; 2.1: |Johnson-Corey-Chaykovsky Reaction / 2.2: |Johnson-Corey-Chaykovsky Reaction / 7.1: |Dess-Martin Oxidation;
DOI:10.5012/bkcs.2013.34.4.1247

Reference yield:

: 88075-18-7
4-(2-(trimethylsilyl)ethynyl)phenol

: 1443542-48-0
(Z)-2,4-bis(4-(methoxymethoxy)phenyl)but-3-enal

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -50 - 0 °C / Inert atmosphere

3.2: 1 h

3.3: 0.5 h / -20 °C

4.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: hydrogen; 10% Pd-CaCO3; quinoline / ethyl acetate / 2 h

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1.08 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; quinoline; n-butyllithium; 10% Pd-CaCO3; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 7.1: |Dess-Martin Oxidation;
DOI:10.5012/bkcs.2013.34.4.1247