{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

Base Information

Chemical Name:{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid
CAS No.:863911-41-5
Molecular Formula:C₂₇H₂₆O₅S
Molecular Weight:462.566
Hs Code.:

Synonyms:{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

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Chemical Property of {3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

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Technology Process of {3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

There total 14 articles about {3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 863911-73-3
[3-[2-(1,1-diphenylethylsulfanyl)ethyl]-2-hydroxymethylbenzofuran-7-yloxy]acetic acid methyl ester

: 863911-41-5
{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 1h;
DOI:10.1021/jm050194z

Reference yield:

: 181053-00-9
2-hydroxymethyl-7-methoxy-benzofuran-3-one

: 863911-41-5
{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h / 20 °C

2: Zn; iodine / tetrahydrofuran / 1.5 h / 20 - 50 °C

3: 15.0 g / pyridine; Tf₂O / toluene / 1.5 h / 0 °C

4: 51 percent / LiAlH₄ / tetrahydrofuran / 6 h / 0 °C

5: t-BuOK; n-PrSH / dimethylformamide / 1 h / 140 °C

6: 7.54 g / K₂CO₃ / dimethylformamide / 15 h / 20 °C

7: Et₃N / CH₂Cl₂ / 3.5 h / 0 °C

8: t-BuOK / dimethylformamide / 1 h / 20 °C

9: 83 percent / pyridinium p-toluenesulfonate / tetrahydrofuran; methanol / 6.5 h / 80 °C

10: 89 percent / aq. NaOH / methanol / 1 h / 20 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; 1-thiopropane; trifluoromethylsulfonic anhydride; potassium tert-butylate; iodine; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2: Reformatski reaction;
DOI:10.1021/jm050194z

Reference yield:

: 863911-63-1
7-methoxy-2-(tetrahydropyran-2-yloxymethyl)benzofuran-3-one

: 863911-41-5
{3-[2-(1,1-diphenyl-ethylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: Zn; iodine / tetrahydrofuran / 1.5 h / 20 - 50 °C

2: 15.0 g / pyridine; Tf₂O / toluene / 1.5 h / 0 °C

3: 51 percent / LiAlH₄ / tetrahydrofuran / 6 h / 0 °C

4: t-BuOK; n-PrSH / dimethylformamide / 1 h / 140 °C

5: 7.54 g / K₂CO₃ / dimethylformamide / 15 h / 20 °C

6: Et₃N / CH₂Cl₂ / 3.5 h / 0 °C

7: t-BuOK / dimethylformamide / 1 h / 20 °C

8: 83 percent / pyridinium p-toluenesulfonate / tetrahydrofuran; methanol / 6.5 h / 80 °C

9: 89 percent / aq. NaOH / methanol / 1 h / 20 °C

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; 1-thiopropane; trifluoromethylsulfonic anhydride; potassium tert-butylate; iodine; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Reformatski reaction;
DOI:10.1021/jm050194z