Technology Process of C16H22NO4P
There total 9 articles about C16H22NO4P which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trimethylsilyl bromide
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane
3.1: tetrahydrofuran / -78 °C
4.1: water / 90 °C
5.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux
5.2: Reflux
6.1: triethylamine / dichloromethane
7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,2-dimethoxyethane / 80 °C
8.1: ozone / methanol / -78 °C
With
tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;
7.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.036
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; potassium acetate / tetrahydrofuran / 22 h / 68 °C
2.1: trimethylsilyl bromide
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane
4.1: tetrahydrofuran / -78 °C
5.1: water / 90 °C
6.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux
6.2: Reflux
7.1: triethylamine / dichloromethane
8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,2-dimethoxyethane / 80 °C
9.1: ozone / methanol / -78 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; potassium acetate; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;
8.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.036