tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate
CAS No.:1436426-81-1
Molecular Formula:C₃₃H₄₁ClF₅N₅O₅
Molecular Weight:718.164
Hs Code.:

tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

Synonyms:tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174632-70-2
4-(bromomethyl)-2,3-difluorobenzoic acid

: 1436426-21-9
4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline

: 183742-33-8,1217683-44-7
3-(methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester

: 1436426-81-1
tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: 4-(bromomethyl)-2,3-difluorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;

4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

3-(methoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 261763-37-5
2,3-difluoro-4-methylbenzoic acid

: 1436426-81-1
tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 90 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 1 h / 20 °C / Cooling with ice

2.3: 1 h / 80 °C

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1436426-81-1
tert-butyl 4-(4-(4-chloro-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)phenylcarbamoyl)-2,3-difluorobenzyl)-3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / Reflux

3.1: ethanol; tin(ll) chloride / 1 h / 80 °C / Cooling with ice

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 1 h / 20 °C / Cooling with ice

4.3: 1 h / 80 °C

With oxalyl dichloride; ethanol; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;