C₂₅H₂₀BrN₃O₄S₂

Base Information

• Chemical Name: C₂₅H₂₀BrN₃O₄S₂
• CAS No.: 591209-31-3
• Molecular Formula: C₂₅H₂₀BrN₃O₄S₂
• Molecular Weight: 570.487
• Mol file: 591209-31-3.mol

Synonyms:C₂₅H₂₀BrN₃O₄S₂

Chemical Property of C₂₅H₂₀BrN₃O₄S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₀BrN₃O₄S₂

There total 17 articles about C₂₅H₂₀BrN₃O₄S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

(+)-5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-methoxy-10-spiro-4'-(2'-bromo)cyclohexa-2',5'-dien-1'-one (613223-61-3) → C25H20BrN3O4S2 (591209-31-3) + C25H21N3O4S2 + C25H20BrN3O4S2

Guidance literature:

(+)-5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-methoxy-10-spiro-4'-(2'-bromo)cyclohexa-2',5'-dien-1'-one; With hydrogen bromide; p-methoxybenzylmercaptan; acetic acid; In dichloromethane; at -78 - 4 ℃; for 36h;

With methylamine; In dichloromethane; water;

DOI:10.1039/c1ob05058c

Reference yield: 22.0%

(+)-5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-methoxy-10-spiro-4'-(2'-bromo)cyclohexa-2',5'-dien-1'-one (613223-61-3) → C25H20BrN3O4S2 (591209-31-3)

Guidance literature:

(+)-5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-methoxy-10-spiro-4'-(2'-bromo)cyclohexa-2',5'-dien-1'-one; With hydrogen bromide; p-methoxybenzylmercaptan; acetic acid;

With methylamine; In water;

DOI:10.1016/j.tet.2008.11.051

Reference yield:

2-nitroveratraldehyde (55149-84-3) → C25H20BrN3O4S2 (591209-31-3) + C25H21N3O4S2 + C25H20BrN3O4S2

Guidance literature:

Multi-step reaction with 12 steps

1: potassium hydroxide / ethanol; N,N-dimethyl-formamide / 1.25 h / -2 °C

2: palladium on carbon; formic acid; ammonium formate / methanol / 1 h

3: 2 h / 0 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / Reflux

5: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / toluene / 9 h

6: potassium tert-butylate / tetrahydrofuran / 6 h / 0 °C

7: 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; bis-[(trifluoroacetoxy)iodo]benzene / water / 1 h / 0 °C

8: hydrogenchloride / methanol / 36 h / 20 °C

9: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 7 h / 20 °C

10: boron trifluoride diethyl etherate / dichloromethane / 7 h / 0 - 20 °C

11: iodopentafluorobenzene bis(trifluoroacetate); sodium hydrogencarbonate / methanol; acetonitrile / 1.5 h / 20 °C / Molecular sieve

12: hydrogen bromide; p-methoxybenzylmercaptan; acetic acid / dichloromethane / 36 h / -78 - 4 °C

With hydrogenchloride; lithium aluminium tetrahydride; formic acid; 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; iodopentafluorobenzene bis(trifluoroacetate); diphenyl phosphoryl azide; palladium on carbon; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen bromide; ammonium formate; sodium hydrogencarbonate; p-methoxybenzylmercaptan; acetic acid; triphenylphosphine; bis-[(trifluoroacetoxy)iodo]benzene; potassium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 5: Mitsunobu reaction / 12: Michael addition;

DOI:10.1039/c1ob05058c

upstream raw materials:

(+)-5-(toluene-4-sulfonyl)-3,5,7,8,9,10-hexahydro-2H-1,5,7-triazaacephenanthrylen-6-one-8-methoxy-10-spiro-4'-(2'-bromo)cyclohexa-2',5'-dien-1'-one

6,7-dimethoxy-1H-indole

2-nitroveratraldehyde

3,4-dimethoxy-2,β-dinitrostyrene