(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

Base Information

Chemical Name:(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole
CAS No.:833459-71-5
Molecular Formula:C₁₉H₂₁NOS
Molecular Weight:311.448
Hs Code.:

(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ<sup>4</sup>-1,2-benzoisothiazole

Synonyms:(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

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Technology Process of (Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

There total 4 articles about (Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

: 772-38-3
4-tert-Butylphenylacetylene

: 833459-47-5
(2-bromophenyl)(imino)(methyl)-λ⁶-sulfanone

: 833459-71-5
(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

: 3-(4-tert-butyphenyl)-1-methyl-1-oxide-1λ⁴-1,2-benzothiazine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 65 - 70 ℃; for 9h;
DOI:10.1021/ol047781j

Reference yield:

: 126218-83-5,146235-11-2,7321-58-6
1-bromo-2-(methylsulfinyl)benzene

: 833459-71-5
(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 6.6 g / sodium azide; sulfuric acid / CHCl₃ / 12 h / 45 °C

2: 68.8 percent / CuI; Pd(PPh₃)2Cl₂; triethylamine / dimethylformamide / 9 h / 65 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; sulfuric acid; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol047781j

Reference yield:

: 6320-02-1
o-bromothiophenol

: 833459-71-5
(Z)-3-(4-tert-butylbenzylidene)-1-methyl-1-oxide-3H-1λ⁴-1,2-benzoisothiazole

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / ethanol / 2 h

2: H₂O₂; H₂SO₄ / methanol; propan-2-ol / 3 h

3: 6.6 g / sodium azide; sulfuric acid / CHCl₃ / 12 h / 45 °C

4: 68.8 percent / CuI; Pd(PPh₃)2Cl₂; triethylamine / dimethylformamide / 9 h / 65 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; sodium azide; sulfuric acid; dihydrogen peroxide; triethylamine; In methanol; ethanol; chloroform; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/ol047781j