N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide

Base Information

• Chemical Name: N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide
• CAS No.: 1452520-13-6
• Molecular Formula: C₂₂H₂₄Cl₂N₄O₂
• Molecular Weight: 447.364

Synonyms:N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide

Chemical Property of N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide

Chemical Property:

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Technology Process of N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide

There total 5 articles about N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-[1-(2,4-dichlorobenzyl)piperidin-4-yl]methanamine (1019380-80-3) + 5-methoxy-1H-indazole-3-carboxylic acid (90417-53-1) → N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide (1452520-13-6)

Guidance literature:

5-methoxy-1H-indazole-3-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

1-[1-(2,4-dichlorobenzyl)piperidin-4-yl]methanamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b01208

Reference yield:

1-[1-(2,4-dichlorobenzyl)piperidin-4-yl]methanamine (1019380-80-3) + 2,10-dimethoxy-7H,14H-pyrazino[1,2-b:4,5-b']di-indazole-7,14-dione (1452520-86-3) → N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide (1452520-13-6)

Guidance literature:

With triethylamine; In toluene; for 12h; Reflux;

Reference yield:

2,10-dimethoxy-7H,14H-pyrazino[1,2-b:4,5-b']di-indazole-7,14-dione (1452582-69-2) + 1-[1-(2,4-dichlorobenzyl)piperidin-4-yl]methanamine (1019380-80-3) → N-{ [1-(2,4-dichlorobenzyl)piperidin-4-yl]methyl}-5-methoxy-1H-indazole-3-carboxamide (1452520-13-6)

Guidance literature:

With triethylamine; In toluene; for 12h; Reflux;

upstream raw materials:

1-[1-(2,4-dichlorobenzyl)piperidin-4-yl]methanamine

2,10-dimethoxy-7H,14H-pyrazino[1,2-b:4,5-b']di-indazole-7,14-dione

5-methoxy-1H-indazole-3-carboxylic acid

2,10-dimethoxy-7H,14H-pyrazino[1,2-b:4,5-b']di-indazole-7,14-dione

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