1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

Base Information

Chemical Name:1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole
CAS No.:586344-99-2
Molecular Formula:C₄₃H₄₆N₂P₂
Molecular Weight:652.799
Hs Code.:

Synonyms:1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

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Chemical Property of 1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

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Technology Process of 1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

There total 5 articles about 1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1732-66-7
dimesityl phosphine

: 586344-98-1
1-[2-(chloromethyl)-3-(diphenylphosphanyl)-2-phenylpropyl]-1H-pyrazole

: 586344-99-2
1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

Guidance literature:: dimesityl phosphine; With potassium tert-butylate; In dimethyl sulfoxide; at 25 ℃; for 0.333333h;

1-[2-(chloromethyl)-3-(diphenylphosphanyl)-2-phenylpropyl]-1H-pyrazole; In dimethyl sulfoxide; for 15h;
DOI:10.1002/ejic.200200448

Reference yield:

: 1865-29-8
2-phenyl-acrylic acid methyl ester

: 586344-99-2
1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 62 percent / dimethylformamide

2.1: 56 percent / PPh₃; CCl₄ / 12 h / Heating

3.1: 96 percent / LiAlH₄ / tetrahydrofuran / 15 h / 25 °C

4.1: nBuLi; methanesulfonyl chloride / tetrahydrofuran / -30 - 0 °C

4.2: 55 percent / nBuLi / tetrahydrofuran / 15 h / 25 °C

5.1: KOtBu / dimethylsulfoxide / 0.33 h / 25 °C

5.2: 63 percent / dimethylsulfoxide / 15 h

With tetrachloromethane; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; sodium hydride; methanesulfonyl chloride; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejic.200200448

Reference yield:

: 586344-97-0
2-(chloromethyl)-2-phenyl-3-(1-pyrazolyl)propan-1-ol

: 586344-99-2
1-{2-[(dimesitylphosphanyl)methyl]-3-(diphenylphosphanyl)-2-phenylpropyl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi; methanesulfonyl chloride / tetrahydrofuran / -30 - 0 °C

1.2: 55 percent / nBuLi / tetrahydrofuran / 15 h / 25 °C

2.1: KOtBu / dimethylsulfoxide / 0.33 h / 25 °C

2.2: 63 percent / dimethylsulfoxide / 15 h

With n-butyllithium; potassium tert-butylate; methanesulfonyl chloride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/ejic.200200448