(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

Base Information

Chemical Name:(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate
CAS No.:1355163-06-2
Molecular Formula:C₂₅H₂₆N₂O₅
Molecular Weight:434.492
Hs Code.:

Synonyms:(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

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Chemical Property of (R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

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Technology Process of (R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

There total 3 articles about (R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1355163-05-1
(E)-ethyl-5-methoxy-3-oxo-4-pentenoate

: 63229-68-5,73327-10-3,84094-71-3
D-(+)-N_bbenzyltryptophan methyl ester

: 1355163-06-2
(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

Guidance literature:: With acetic acid; In acetonitrile; at 0 - 75 ℃; for 15.5h; Inert atmosphere;
DOI:10.1021/np200759h

Reference yield:

: 63229-68-5,73327-10-3,84094-71-3
D-(+)-N_bbenzyltryptophan methyl ester

: 217447-41-1
methyl 5,5-dimethoxy-3-oxo-4-pentanoate

: 1355163-06-2
(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

Guidance literature:: With acetic acid; In acetonitrile; at 0 - 75 ℃; for 40h; Inert atmosphere;
DOI:10.1021/np200759h

Reference yield:

: 217447-41-1
methyl 5,5-dimethoxy-3-oxo-4-pentanoate

: 1355163-06-2
(R,E)-methyl-5-((3-(1H-indol-3-yl)-1-methoxy-1-oxo-propan-2-yl)(benzyl)amino)-3-oxopent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3.17 h / 0 - 20 °C / Inert atmosphere

2: acetic acid / acetonitrile / 15.5 h / 0 - 75 °C / Inert atmosphere

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; acetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/np200759h