Multi-step reaction with 4 steps
1: 53.8 percent / AlCl3 / CH2Cl2 / Ambient temperature
2: 1.) LDA, diethyl chlorophosphate, 2.) LDA / 1.) THF, -78 deg C, 15 min, then room temp., 3 h, 2.) THF, room temp., overnight
3: 1.) t-BuLi, 2.) I2 / 1.) ether, pentane, -78 deg C, 30 min, 2.) ether, pentane, 0 deg C, 10 min
4: 70 percent / Pd(dba)2, PPh3, CuI, diisopropylamine / dimethylformamide / 2 h / 60 °C
With
copper(l) iodide; aluminium trichloride; iodine; tert.-butyl lithium; diethyl chlorophosphate; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0); lithium diisopropyl amide;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982392m