N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

Base Information

Chemical Name:N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine
CAS No.:328554-50-3
Molecular Formula:C₁₈H₁₇FN₄O₂S
Molecular Weight:372.423
Hs Code.:

<i>N</i>-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1<i>H</i>-pyrazol-3-yl]-acetamidine

Synonyms:N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

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Chemical Property of N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

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Technology Process of N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

There total 3 articles about N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2208-07-3
ethyl acetimidate hydrochloride

: 328553-87-3
3-amino-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazole

: 328554-50-3
N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

Guidance literature:: ethyl acetimidate hydrochloride; With potassium carbonate; In acetonitrile; for 0.0833333h;

3-amino-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazole; With acetic acid; In acetonitrile; at 20 ℃; for 18h; Further stages.;
DOI:10.1021/jm0009383

Reference yield:

: 163304-90-3
2-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)ethanone

: 328554-50-3
N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃ / CHCl₃ / 0.25 h / 0 °C

1.2: CHCl₃ / 18 h / 80 °C

1.3: NH₂OH*HCl / dimethylformamide / 4 h / 20 °C

2.1: 52 percent / NH₂NH₂*H₂O / ethanol / 18 h / 78 °C

3.1: K₂CO₃ / acetonitrile / 0.08 h

3.2: AcOH / acetonitrile / 18 h / 20 °C

With potassium carbonate; hydrazine hydrate; trichlorophosphate; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm0009383

Reference yield:

: 3-chloro-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propenenitrile

: 328554-50-3
N-[4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazol-3-yl]-acetamidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 52 percent / NH₂NH₂*H₂O / ethanol / 18 h / 78 °C

2.1: K₂CO₃ / acetonitrile / 0.08 h

2.2: AcOH / acetonitrile / 18 h / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; acetonitrile;
DOI:10.1021/jm0009383