2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Base Information

Chemical Name:2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid
CAS No.:935470-37-4
Molecular Formula:C₂₀H₂₅N₃O₄S
Molecular Weight:403.502
Hs Code.:

Synonyms:2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

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Chemical Property of 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

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Technology Process of 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

There total 9 articles about 2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853304-06-0
methyl 2-chloro-6-[methyl(methylsulfonyl)amino]isonicotinate

: 935470-37-4
2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 16 h / 20 °C

2: 77 percent / K₃PO₄ / Pd[P(tBu)3]2 / N,N-dimethyl-acetamide / 4 h / 130 °C

With lithium hydroxide; potassium phosphate; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1021/jm070272d

Reference yield:

: 959774-49-3
(1S,2S)-N-benzyl-2-methylcyclopropane-1-carboxamide

: 935470-37-4
2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / borane-THF / tetrahydrofuran / 16 h / Heating

2: 77 percent / K₃PO₄ / Pd[P(tBu)3]2 / N,N-dimethyl-acetamide / 4 h / 130 °C

With potassium phosphate; borane-THF; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jm070272d

Reference yield:

: 42521-09-5
methyl 2,6-dichloroisonicotinate

: 935470-37-4
2-(benzyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / K₃PO₄; Xantphos / Pd₂dba3 / dioxane / 16 h / 100 °C

2: 77 percent / lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 16 h / 20 °C

3: 77 percent / K₃PO₄ / Pd[P(tBu)3]2 / N,N-dimethyl-acetamide / 4 h / 130 °C

With lithium hydroxide; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm070272d