dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate

Base Information

• Chemical Name: dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate
• CAS No.: 109873-38-3
• Molecular Formula: C₁₇H₂₆O₆
• Molecular Weight: 326.39
• Mol file: 109873-38-3.mol

Synonyms:dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate

Chemical Property of dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate

There total 2 articles about dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid tert-butyl ester (540-88-5) + diethyl 3-hydroxyglutarate (32328-03-3) → dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate (109873-38-3)

Guidance literature:

With calcium acetate; lithium diisopropyl amide; Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)96034-9

Reference yield:

diethyl 3-hydroxyglutarate (32328-03-3) + t-butyl lithioacetate (150942-98-6) → dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate (109873-38-3)

Guidance literature:

With calcium acetate; Yield given. Multistep reaction;

DOI:10.1021/jo00292a041

Reference yield: 89.0%

dl-tert-butyl 2-tert-butoxycarbonyl-5-hydroxy-3-oxo-1-cyclohexene-1-acetate (109873-38-3) → tert-butyl 2-tert-butoxycarbonyl-3,5-dihydroxybenzene-1-acetate (109873-40-7)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In acetone; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)81434-4

upstream raw materials:

acetic acid tert-butyl ester

diethyl 3-hydroxyglutarate

t-butyl lithioacetate

Downstream raw materials:

tert-butyl 2-tert-butoxycarbonyl-3,5-dihydroxybenzene-1-acetate

2,4-Diacetoxy-6-[1-tert-butoxycarbonyl-meth-(E)-ylidene]-cyclohex-1-enecarboxylic acid tert-butyl ester

4-Acetoxy-2-tert-butoxycarbonylmethyl-6-oxo-cyclohex-1-enecarboxylic acid tert-butyl ester

tert-butyl 2-tert-butoxycarbonyl-3,5-dimethoxybenzene-1-acetate