ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Base Information

Chemical Name:ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate
CAS No.:148366-87-4
Molecular Formula:C₃₃H₃₇NO₄
Molecular Weight:511.661
Hs Code.:

Synonyms:ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Suppliers and Price of ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

There total 8 articles about ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.7%

: 130007-66-8
R-(-)-2-(4-isobutyl-phenyl)-2-hydroxyethane

: 139155-89-8
ethyl 4-{3-(4-Hydroxybenzoyl)indol-1-yl}butanoate

: 148366-88-5
ethyl (S)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

: 148366-87-4
ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at -20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1248/cpb.49.799

Reference yield: 58.0%

: 125653-66-9
(S)-(-)-1-(4-isobutylphenyl)ethanol

: 139155-89-8
ethyl 4-{3-(4-Hydroxybenzoyl)indol-1-yl}butanoate

: 148366-87-4
ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at -20 ℃; for 1h;
DOI:10.1248/cpb.49.799

Reference yield:

: 120-72-9
indole

: 148366-87-4
ethyl (R)-4-[3-[4-[[1-(4-isobutylphenyl)ethyl]oxy]benzoyl]-1H-indol-1-yl]butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 78.4 percent / CH₂Cl₂ / 1 h

2.1: 100 percent / K₂CO₃ / dimethylformamide / 14 h / 20 °C

3.1: 83.5 percent / AlCl₃; ethanethiol / CH₂Cl₂ / 1.5 h / 20 °C

4.1: 58 percent / DEAD; PPh₃ / tetrahydrofuran; toluene / 1 h / -20 °C

With aluminium trichloride; potassium carbonate; triphenylphosphine; ethanethiol; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799