(2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate

Base Information

• Chemical Name: (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate
• CAS No.: 1234491-62-3
• Molecular Formula: C₂₀H₁₇ClF₂NO₄P
• Molecular Weight: 439.783

Synonyms:(2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate

Chemical Property of (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate

Chemical Property:

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Technology Process of (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate

There total 1 articles about (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate (1234491-62-3)

Guidance literature:

Reference yield:

(2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate (1234491-62-3) + (2R,3S,4R,5R)-2-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-3-ol (1434144-20-3) → (2S)-2,4-difluorobenzyl 2-((((2R,3R,4S,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphorylamino)propanoate

Guidance literature:

With tert-butylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 12.25h;

Reference yield:

(2R,3R,4R,5R)-2-(2-amino-6-ethoxy-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol (1106011-12-4) + (2S)-2,4-difluorobenzyl 2-(chloro(naphthalene-1-yloxy)phosphorylamino)propanoate (1234491-62-3) → (2S)-2,4-difluorobenzyl 2-((((2R,3R,4R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalene-1-yloxy)phosphorylamino)propanoate (1234491-38-3)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.06.013

Downstream raw materials:

(2S)-2,4-difluorobenzyl 2-((((2R,3R,4R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalene-1-yloxy)phosphorylamino)propanoate

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