(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

Base Information

Chemical Name:(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane
CAS No.:146499-37-8
Molecular Formula:C₁₆H₁₈Cl₃NO₆
Molecular Weight:426.681
Hs Code.:

Synonyms:(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

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Chemical Property of (2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

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Technology Process of (2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

There total 5 articles about (2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 153704-80-4
(2R,3R)-1,2-dihydroxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

: 146499-37-8
(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

Guidance literature:: With pyridine; In dichloromethane; for 19h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 146499-37-8
(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 3 steps

1: HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

2: 99 percent / KHCO₃ / ethyl acetate; H₂O / 1 h / Ambient temperature

3: 94 percent / pyridine / CH₂Cl₂ / 19 h / Ambient temperature

With pyridine; ammonium formate; potassium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)88039-X

Reference yield:

: 104196-23-8
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol

: 146499-37-8
(2R,3R)-1,2-diacetoxy-3-(2,2,2-trichloroethoxycarbonylamino)-3-phenylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: NaN₃, NH₄Cl / methanol; H₂O / 10 h / 70 °C

2: HCO₂NH₄ / 10 percent Pd-C / methanol / 2 h / Ambient temperature

3: 99 percent / KHCO₃ / ethyl acetate; H₂O / 1 h / Ambient temperature

4: 94 percent / pyridine / CH₂Cl₂ / 19 h / Ambient temperature

With pyridine; sodium azide; ammonium formate; ammonium chloride; potassium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)88039-X