(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate
CAS No.:1422173-33-8
Molecular Formula:C₁₆H₁₇F₄NO₄
Molecular Weight:363.309
Hs Code.:

Synonyms:(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

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Chemical Property of (2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

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Technology Process of (2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

There total 3 articles about (2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203866-16-4
1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate

: 1422173-33-8
(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 23 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja3125405

Reference yield:

: 847866-34-6
methyl (4S)-4-fluoro-L-prolinate trifluoroacetate

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1422173-33-8
(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/ja3125405

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 1422173-33-8
(2S,4S)-methyl-4-fluoro-1-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; potassium fluoride; N-ethyl-N,N-diisopropylamine / toluene / 16 h / 80 °C / Inert atmosphere

2: dichloromethane / 1 h / 23 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With potassium fluoride; 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/ja3125405