8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Base Information

Chemical Name:8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one
CAS No.:1401993-39-2
Molecular Formula:C₃₂H₃₆F₃N₃O₅
Molecular Weight:599.65
Hs Code.:

8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Synonyms:8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Chemical Property of 8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

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Technology Process of 8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

There total 2 articles about 8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 708273-57-8
4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone

: 3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one hydrochloride

: 1401993-39-2
8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 708273-57-8
4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone

: 1401993-87-0
3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one hydrochloride

: 1401993-39-2
8-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]-3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one

Guidance literature:: 4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone; 3-methyl-4-{[7-(trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-en-2-one hydrochloride; With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 12h;

With water; In dichloromethane; 1,2-dichloro-ethane;