2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester

Base Information

• Chemical Name: 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester
• CAS No.: 870621-97-9
• Molecular Formula: C₁₄H₁₉NO₂Si
• Molecular Weight: 261.396
• Mol file: 870621-97-9.mol

Synonyms:2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester

Chemical Property of 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester

There total 2 articles about 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-amino-5-iodobenzoate (268568-11-2) + trimethylsilylacetylene (1066-54-2) → 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester (870621-97-9)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In triethylamine; at 50 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.06.173

Reference yield:

2-ethoxycarbonylaniline (87-25-2) → 2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester (870621-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / I₂; Ag₂SO₄ / ethanol / 1 h / 20 °C

2: 90 percent / CuI / Pd(PPh₃)4 / triethylamine / 4 h / 50 °C

With copper(l) iodide; iodine; silver sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; triethylamine;

DOI:10.1016/j.tetlet.2005.06.173

Reference yield: 86.0%

2-amino-5-trimethylsilanylethynyl-benzoic acid ethyl ester (870621-97-9) + 2,5-bis(hexyloxy)terephthaloxy chrloride (103761-95-1) → C48H64N2O8Si2 (870621-98-0)

Guidance literature:

With triethylamine; In chloroform; for 2h; Heating;

DOI:10.1016/j.tetlet.2005.06.173

upstream raw materials:

ethyl 2-amino-5-iodobenzoate

trimethylsilylacetylene

2-ethoxycarbonylaniline

Downstream raw materials:

C₄₈H₆₄N₂O₈Si₂