{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

Base Information

Chemical Name:{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide
CAS No.:132375-31-6
Molecular Formula:C₃₆H₄₄O₃PSi*I
Molecular Weight:710.707
Hs Code.:

Synonyms:{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

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Chemical Property of {2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

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Technology Process of {2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

There total 6 articles about {2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 132375-35-0
tert-Butyl-[(4S,5R)-4-(2-iodo-ethyl)-2-phenyl-[1,3]dioxan-5-yloxy]-dimethyl-silane

: 603-35-0
triphenylphosphine

: 132375-31-6
{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

Guidance literature:: In acetonitrile; at 80 ℃; for 48h;

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 132375-31-6
{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

Guidance literature:: Multi-step reaction with 5 steps

1: 2) camphersulfonic acid / 1) THF, 80 deg C, 4 h, 2) CH₂Cl₂, 25 deg C, 12 h

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

3: 1) ozone, 2) NaBH₄ / 1) CH₂Cl₂, -78 deg C, 2 h, 2) MeOH, 0 deg C, 2 h

4: 84 percent / I₂, PPh₃, imidazole / acetonitrile / 0.5 h / 25 °C

5: 90 percent / acetonitrile / 48 h / 80 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; camphor-10-sulfonic acid; iodine; ozone; triphenylphosphine; In dichloromethane; acetonitrile;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 132375-31-6
{2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl}-triphenyl-phosphonium; iodide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 1) ozone, 2) NaBH₄ / 1) CH₂Cl₂, -78 deg C, 2 h, 2) MeOH, 0 deg C, 2 h

3: 84 percent / I₂, PPh₃, imidazole / acetonitrile / 0.5 h / 25 °C

4: 90 percent / acetonitrile / 48 h / 80 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; iodine; ozone; triphenylphosphine; In dichloromethane; acetonitrile;