17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

Base Information

Chemical Name:17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one
CAS No.:646033-37-6
Molecular Formula:C₃₀H₃₅NO₄
Molecular Weight:473.612
Hs Code.:

Synonyms:17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

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Chemical Property of 17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

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Technology Process of 17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

There total 6 articles about 17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 528854-52-6
14-cinnamyloxycodeinone

: 646033-37-6
17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / H₂; AcOH / Pd/C / 3 h / 20 °C / 1551.44 Torr

2.1: 1-chloroethyl chloroformate; NaHCO₃ / 1,2-dichloro-ethane / 17 h / Heating

2.2: 4.9 g / methanol / 1 h / Heating

3.1: K₂CO₃ / dimethylformamide / 24 h / 80 °C

4.1: aq. HBr / Heating

With carbonochloridic acid 1-chloro-ethyl ester; hydrogen bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; palladium on activated charcoal; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm021118o

Reference yield:

: 17247-58-4
(Bromomethyl)cyclobutane

: 646033-37-6
17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 24 h / 80 °C

2: aq. HBr / Heating

With hydrogen bromide; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm021118o

Reference yield:

: 528854-53-7
4,5α-epoxy-3-methoxy-17-methyl-14β-(3-phenylpropyloxy)morphinan-6-one

: 646033-37-6
17-cyclobutylmethyl-4,5α-epoxy-3-hydroxy-14β-(3-phenylpropyloxy)morphinan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-chloroethyl chloroformate; NaHCO₃ / 1,2-dichloro-ethane / 17 h / Heating

1.2: 4.9 g / methanol / 1 h / Heating

2.1: K₂CO₃ / dimethylformamide / 24 h / 80 °C

3.1: aq. HBr / Heating

With carbonochloridic acid 1-chloro-ethyl ester; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm021118o