N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide
• CAS No.: 1346508-03-9
• Molecular Formula: C₃₁H₄₅N₇O₁₅S₂
• Molecular Weight: 819.868
• Mol file: 1346508-03-9.mol

Synonyms:N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide

Chemical Property of N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide

There total 1 articles about N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

Gentamicin C1a (26098-04-4) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide (1346508-03-9)

Guidance literature:

Gentamicin C₁a; With zinc(II) acetate dihydrate; In methanol; at 20 ℃; for 1h;

2-Nitrobenzenesulfonyl chloride; With triethylamine; In methanol; dichloromethane; at -60 - 20 ℃; for 18h;

With ammonium hydroxide; In dichloromethane; for 1h;

Reference yield: 67.0%

di-tert-butyl dicarbonate (24424-99-5) + N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide (1346508-03-9) → tert-butyl (1S,2R,3R,4S,5R)-5-amino-4-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-3-hydroxy-2-((2R,3R,6S)-3-(2-nitrophenylsulfonamido)-6-((2-nitrophenylsulfonamido)methyl)tetrahydro-2H-pyran-2-yloxy)cyclohexylcarbamate (1346508-04-0)

Guidance literature:

N-(((2S,5R,6R)-6-((lR,2S,3S,4R,6S)-4,6-diamino-3-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-(2-nitrophenylsulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2-nitrobenzenesulfonamide; With zinc(II) acetate dihydrate; In methanol; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

With ammonium hydroxide; In dichloromethane; water; for 0.5h;

upstream raw materials:

Gentamicin C1a

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

tert-butyl (1S,2R,3R,4S,5R)-5-amino-4-((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yloxy)-3-hydroxy-2-((2R,3R,6S)-3-(2-nitrophenylsulfonamido)-6-((2-nitrophenylsulfonamido)methyl)tetrahydro-2H-pyran-2-yloxy)cyclohexylcarbamate