[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Base Information

Chemical Name:[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid
CAS No.:1161932-99-5
Molecular Formula:C₂₀H₁₆F₂N₂O₃
Molecular Weight:370.355
Hs Code.:

Synonyms:[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

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Technology Process of [2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

There total 7 articles about [2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1355046-37-5
[6-fluoro-2-(4-fluorobenzyl)-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid methyl ester

: 1161932-99-5
[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In methanol; for 1h; Reflux;
DOI:10.1016/j.bmc.2011.10.073

Reference yield:

: 110977-72-5
C₉H₁₂O₅

: 1161932-99-5
[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

2.1: 220 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: lithium hydroxide monohydrate; water / methanol / 1 h / Reflux

With lithium hydroxide monohydrate; water; sodium hydride; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.073

Reference yield:

: 1161933-45-4
6-fluoro-2-(4-fluorobenzyl)-2,3,4,9-tetrahydro-β-carbolin-1-one

: 1161932-99-5
[2-(4-fluorobenzyl)-6-fluoro-1-oxo-1,2,3,4-tetrahydro-β-carbolin-9-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 24 h / 0 - 20 °C

2.1: lithium hydroxide monohydrate; water / methanol / 1 h / Reflux

With lithium hydroxide monohydrate; water; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.073