5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol

Base Information

Chemical Name:5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol
CAS No.:32362-88-2
Molecular Formula:C7H6N4S
Molecular Weight:178.217
Hs Code.:2933990090
European Community (EC) Number:625-823-8
NSC Number:625812
Nikkaji Number:J1.650.335E
ChEMBL ID:CHEMBL1968993
Mol file:32362-88-2.mol

Synonyms:32362-88-2;5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol;5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol;1,2-Dihydro-5-(3-pyridinyl)-3H-1,2,4-triazole-3-thione;5-pyridin-3-yl-1,2-dihydro-1,2,4-triazole-3-thione;5-(pyridin-3-yl)-1H-1,2,4-triazole-3-thiol;5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol;MFCD00207933;3-(Pyridin-3-yl)-1H-1,2,4-triazole-5(4H)-thione;3-Methyladipicacid;NSC625812;3-(3-pyridyl)-1H-1,2,4-triazole-5-thiol;5-pyridin-3-yl-4H-1,2,4-triazol-3-yl hydrosulfide;SCHEMBL1233176;SCHEMBL8008602;CHEMBL1968993;GAYWCADKXYCKCG-UHFFFAOYSA-N;3-pyridyl-1,2,4-triazole-5-thiol;CCG-48586;STK803296;STK877680;AKOS000267022;AKOS000295723;AKOS000593509;AKOS023363091;NSC-625812;NCI60_008097;3-Mercapto-5(3-pyridyl)-1,2,4-triazole;3-Mercapto-5-(3-pyridyl)-1,2,4-triazole;FT-0606408;5-pyridin-3-yl-1H-1,2,4-triazole-3-thiol;EN300-52045;5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol;5-pyridin-3-yl-2H-[1,2,4]triazole-3-thiol;4H-1,2,4-Triazole-3-thiol, 5-(3-pyridinyl)-;AF-615/25002792;5-(pyridin-3-yl)-1H-[1,2,4]TRIAZOLE-3-thiol;J-018716;SR-01000638118-1;5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol, 97%;3-(3-PYRIDINYL)-1H-1,2,4-TRIAZOLE-5-THIOL;3-(3-pyridyl)-1,4-dihydro-1,2,4-triazole-5-thione;5-(Pyridin-3-yl)-1H-1,2,4-triazole-3(2H)-thione;Z1245635833;5-(pyridin-3-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Suppliers and Price of 5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol 97%
5g
$ 97.50

Matrix Scientific
5-Pyridin-3-yl-4H-1,2,4-triazole-3-thiol
500mg
$ 237.00

Crysdot
3-(Pyridin-3-yl)-1H-1,2,4-triazole-5(4H)-thione 97%
5g
$ 838.00

American Custom Chemicals Corporation
1,2-DIHYDRO-5-(3-PYRIDINYL)-3H-1,2,4-TRIAZOLE-3-THIONE 95.00%
5G
$ 878.40

AK Scientific
5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol
5g
$ 173.00

Total 9 raw suppliers

Chemical Property of 5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol

Chemical Property:

Vapor Pressure:0.00143mmHg at 25°C
Melting Point:296-302 °C
Refractive Index:1.795
Boiling Point:296.5 °C at 760 mmHg
PKA:7.75±0.20(Predicted)
Flash Point:133.1 °C
PSA：89.45000
Density:1.54 g/cm³
LogP:1.52930
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:178.03131738
Heavy Atom Count:12
Complexity:225

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-37/38-41
Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=CN=C1)C2=NC(=S)NN2
General Description **1,2-Dihydro-5-(3-pyridinyl)-3H-1,2,4-triazole-3-thione** is a key intermediate in the synthesis of pharmacologically active 1,2,4-triazole-pyridine hybrids. It exhibits potential analgesic, anti-inflammatory, and antimicrobial properties when further derivatized with substituted benzyl groups via thio linkages. Docking studies suggest strong binding affinities for targets like cyclooxygenase-2 (COX-2) and dihydrofolate reductase (DHFR), indicating its relevance in drug development for inflammation and infections. 1,2-DIHYDRO-5-(3-PYRIDINYL)-3H-1,2,4-TRIAZOLE-3-THIONE's structural versatility enables the creation of derivatives with enhanced biological activity compared to standard drugs like aspirin, indomethacin, or methotrexate.

Technology Process of 5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol

There total 23 articles about 5-(3-Pyridyl)-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%