4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

Base Information

Chemical Name:4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester
CAS No.:913987-84-5
Molecular Formula:C₄₁H₄₁NO₁₀
Molecular Weight:707.777
Hs Code.:

Synonyms:4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

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Chemical Property of 4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

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Technology Process of 4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

There total 4 articles about 4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 913987-81-2
(4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 913987-84-5
4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 0 ℃;
DOI:10.1055/s-2006-942485

Reference yield:

: 92638-57-8
phenylcarbonylmethyl <4-(hydroxymethyl)phenoxy>acetate

: 913987-84-5
4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaI; TMSCl / acetonitrile / 2 h

2: 94 percent / DIPEA / 0 °C

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile;
DOI:10.1055/s-2006-942485

Reference yield:

: 68858-21-9
[4-(hydroxymethyl)phenoxy]acetic acid

: 913987-84-5
4-[Fmoc-(γ-tert-butyl)glutamyloxymethyl]phenoxyacetic acid 2-phenacyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / ethyl acetate / 20 °C

2: 90 percent / NaI; TMSCl / acetonitrile / 2 h

3: 94 percent / DIPEA / 0 °C

With chloro-trimethyl-silane; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In ethyl acetate; acetonitrile;
DOI:10.1055/s-2006-942485