(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

Base Information

Chemical Name:(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione
CAS No.:439143-52-9
Molecular Formula:C₃₇H₅₃NO₈Si
Molecular Weight:667.915
Hs Code.:

(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

Synonyms:(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

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Chemical Property of (E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

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Technology Process of (E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

There total 1 articles about (E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101712-01-0
(S)-1-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-methylpentane-1,3-dione

: 439143-54-1
(2E)(5S)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(tert-butyldimethylsilyloxy)hex-2-enal

: 439143-52-9
(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

: (E)-(2S,4S,5S,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

Guidance literature:: (S)-1-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-methylpentane-1,3-dione; With dicyclohexylboron chloride; In diethyl ether; at 0 ℃;

(2E)(5S)-6-[(4-methoxyphenyl)methoxy]-3-methyl-5-(tert-butyldimethylsilyloxy)hex-2-enal; In diethyl ether; at -78 - -20 ℃; Further stages.;
DOI:10.1021/ja026235n

Reference yield:

: 439143-52-9
(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

: (S)-4-Benzyl-3-[(E)-(2S,3S,4R,5R,9S)-9-(tert-butyl-dimethyl-silanyloxy)-3,5-dihydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-enoyl]-oxazolidin-2-one

Guidance literature:: With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; at 0 ℃;
DOI:10.1021/ja026235n

Reference yield:

: 439143-52-9
(E)-(2S,4R,5R,9S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-9-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-2,4,7-trimethyl-dec-6-ene-1,3-dione

: 439143-58-5
2-(6-{(1E)(4S)-5-[(4-methoxyphenyl)methoxy]-2-methyl-4-(tert-butyldimethylsilyloxy)pent-1-enyl}(4S,5R,6R)-2,2,5-trimethyl(1,3-dioxan-4-yl))(2S)-N-methoxy-N-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: Me₄NBH(OAc)3; AcOH / acetonitrile / 0 °C

2: HN(CH₂CH₂OH)2 / ethyl acetate / 20 °C

3: AlMe₃ / CH₂Cl₂ / 0 - 20 °C

4: PPTS / acetone / 20 °C

With trimethylaluminum; pyridinium p-toluenesulfonate; acetic acid; 2,2'-iminobis[ethanol]; tetramethylammonium triacetoxyborohydride; In dichloromethane; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/ja026235n