hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester

Base Information

• Chemical Name: hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester
• CAS No.: 32345-57-6
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.203
• Mol file: 32345-57-6.mol

Synonyms:hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester

Chemical Property of hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester

There total 7 articles about hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-hydroxy-2-(3-methoxyphenyl)acetate (54845-40-8) → (R)-m-Methoxymandelic acid (21150-12-9,104528-82-7,104596-00-1,32174-39-3) + hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester (32345-57-6)

Guidance literature:

With water; bovine carbonic anhydrase; at 25 ℃; Bovine carbonic anhydrase catalyzed hydrolysis;

Reference yield:

methyl 2-(3-methoxyphenyl)-2-oxoacetate (83585-22-2) → (R)-(-)-methyl 2-hydroxy-2-(3-methoxyphenyl)acetate + hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester (32345-57-6)

Guidance literature:

With hydrogen; RuCl₂[(S)-C₃-TunePhos](DMF)m; In methanol; at 20 ℃; for 20h; under 3800 Torr; Title compound not separated from byproducts;

DOI:10.1055/s-2006-932461

Reference yield:

methyl 2-(3-methoxyphenyl)-2-oxoacetate (83585-22-2) → hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester (32345-57-6)

Guidance literature:

With hydrogen; dichloro(benzene)ruthenium(II) dimer; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 20h; under 3800.26 Torr;

DOI:10.1021/jo702068w

upstream raw materials:

methyl 2-hydroxy-2-(3-methoxyphenyl)acetate

methyl 2-(3-methoxyphenyl)-2-oxoacetate

methyl 2-diazo-2-(3-methoxyphenyl)acetate

(S)-2-hydroxy-2-(3-methoxyphenyl)acetic acid

Refernces

• 1、 Guo, Huan,Li, Jing,Liu, Delong,Zhang, Wanbin. "The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation". . p. 3665 - 3673. Retrieved 2017/09/11.
• 2、 Zhu, Shou-Fei,Chen, Chao,Cai, Yan,Zhou, Qi-Lin. "Catalytic asymmetric reaction with water: Enantioselective synthesis of α-hydroxyesters by a copper-carbenoid O-H insertion reaction". . p. 932 - 934. Retrieved 2008/09/20.