(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Base Information

Chemical Name:(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol
CAS No.:902118-91-6
Molecular Formula:C₂₆H₂₉F₂N₅O₂Si
Molecular Weight:509.631
Hs Code.:

Synonyms:(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Suppliers and Price of (1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

There total 8 articles about (1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 902118-90-5
(1S,3S,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(6-chloropurin-9-yl)-2,2-difluorocyclopentanol

: 902118-91-6
(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Guidance literature:: With ammonia; In methanol; at 75 ℃; for 24h;
DOI:10.1016/j.bmc.2006.03.011

Reference yield:

: 902118-76-7
9-[(1R,4S)-4-(tert-butyldiphenylsilanyloxy)cyclopent-2-enyl]-6-chloro-9H-purine

: 902118-91-6
(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 88 percent / N-methylmorpholine N-oxide; OsO₄ / tetrahydrofuran; H₂O; acetone / 24 h / 20 °C

2.1: dibutyltin oxide / benzene / 3 h / Heating

2.2: 74 percent / tetrabutylammonium bromide / benzene / 3 h / Heating

3.1: 82 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

4.1: 76 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 24 h / Heating

5.1: 72 percent / ceric ammonium nitrate / acetonitrile; H₂O / 20 h / 20 °C

6.1: 81 percent / NH₃ / methanol / 24 h / 75 °C

With osmium(VIII) oxide; ammonium cerium(IV) nitrate; diethylamino-sulfur trifluoride; ammonia; di(n-butyl)tin oxide; Dess-Martin periodane; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile; benzene;
DOI:10.1016/j.bmc.2006.03.011

Reference yield:

: 902118-77-8
(1S,2S,3S,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(6-chloropurin-9-yl)cyclopentane-1,2-diol

: 902118-91-6
(1S,3S,5R)-5-(6-aminopurin-9-yl)-3-(tert-butyldiphenylsilanyloxy)-2,2-difluorocyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dibutyltin oxide / benzene / 3 h / Heating

1.2: 74 percent / tetrabutylammonium bromide / benzene / 3 h / Heating

2.1: 82 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

3.1: 76 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 24 h / Heating

4.1: 72 percent / ceric ammonium nitrate / acetonitrile; H₂O / 20 h / 20 °C

5.1: 81 percent / NH₃ / methanol / 24 h / 75 °C

With ammonium cerium(IV) nitrate; diethylamino-sulfur trifluoride; ammonia; di(n-butyl)tin oxide; Dess-Martin periodane; In methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/j.bmc.2006.03.011