4,5-Dihydroxy-2-methylbenzoic acid

Base Information

Chemical Name:4,5-Dihydroxy-2-methylbenzoic acid
CAS No.:127531-40-2
Molecular Formula:C₈H₈O₄
Molecular Weight:168.149
Hs Code.:
DSSTox Substance ID:DTXSID201296210
Nikkaji Number:J2.569.929G

Synonyms:4,5-dihydroxy-2-methylbenzoic acid;127531-40-2;SCHEMBL3793157;DTXSID201296210;2-methyl-4,5-dihydroxybenzoic acid;AKOS023769239;CS-0259888;EN300-7432282;Z1255427529

Suppliers and Price of 4,5-Dihydroxy-2-methylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4,5-Dihydroxy-2-methylbenzoic acid

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:168.04225873
Heavy Atom Count:12
Complexity:180

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C=C1C(=O)O)O)O

Technology Process of 4,5-Dihydroxy-2-methylbenzoic acid

There total 5 articles about 4,5-Dihydroxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

: 127531-39-9
4,5-bisbenzyloxy-2-methylbenzoic acid

: 127531-40-2
4,5-dihydroxy-2-methylbenzoic acid

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In isopropyl alcohol; for 2h; under 2327.23 Torr;

Reference yield: 92.0%

: 20736-28-1,131035-49-9
4,5-dimethoxy-2-methylbenzoic acid

: 127531-40-2
4,5-dihydroxy-2-methylbenzoic acid

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1002/ejoc.200700908

Reference yield:

: 452-86-8
4-methyl-1,2-dihydroxybenzene

: 127531-40-2
4,5-dihydroxy-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / dichloromethane / 0.5 h / Cooling with acetone-dry ice

2.1: potassium carbonate / acetone / 0.5 h

2.2: 5 h / Reflux

3.1: magnesium / tetrahydrofuran / 3 h / Cooling with ice

4.1: 5%-palladium/activated carbon; hydrogen / isopropyl alcohol / 2 h / 2327.23 Torr

With 5%-palladium/activated carbon; hydrogen; bromine; potassium carbonate; magnesium; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetone;