2-cyanoethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydro[1]benzothieno[3,2-b]pyridine-3-carboxylate 5,5-dioxide

Base Information

• Chemical Name: 2-cyanoethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydro[1]benzothieno[3,2-b]pyridine-3-carboxylate 5,5-dioxide
• CAS No.: 664973-61-9
• Molecular Formula: C₂₅H₂₄N₂O₇S
• Molecular Weight: 496.541
• Mol file: 664973-61-9.mol

Synonyms:3-(2-cyanoethoxycarbonyl)-2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzothieno[3,2-b]pyridine 5,5-dioxide

Chemical Property of 2-cyanoethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydro[1]benzothieno[3,2-b]pyridine-3-carboxylate 5,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyanoethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydro[1]benzothieno[3,2-b]pyridine-3-carboxylate 5,5-dioxide

There total 3 articles about 2-cyanoethyl 2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydro[1]benzothieno[3,2-b]pyridine-3-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(3,4,5-trimethoxybenzylidene)benzo[b]thiophen-3(2H)one 1,1-dioxide (445221-86-3) + 3-amino-2-butenoic acid 2-cyanoethyl ester → 3-(2-cyanoethoxycarbonyl)-2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzothieno[3,2-b]pyridine 5,5-dioxide (664973-61-9)

Guidance literature:

With acetic acid; for 1h; Reflux;

DOI:10.1016/j.tet.2013.04.060

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 3-(2-cyanoethoxycarbonyl)-2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzothieno[3,2-b]pyridine 5,5-dioxide (664973-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; piperidine / 0.5 h / Reflux

2: acetic acid / 1 h / Reflux

With piperidine; acetic acid;

DOI:10.1016/j.tet.2013.04.060

Reference yield:

1-benzothiophen-3(2H)-one 1,1-dioxide (1127-35-1) → 3-(2-cyanoethoxycarbonyl)-2-methyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzothieno[3,2-b]pyridine 5,5-dioxide (664973-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; piperidine / 0.5 h / Reflux

2: acetic acid / 1 h / Reflux

With piperidine; acetic acid;

DOI:10.1016/j.tet.2013.04.060

upstream raw materials:

2-(3,4,5-trimethoxybenzylidene)benzo[b]thiophen-3(2H)one 1,1-dioxide

3,4,5-trimethoxy-benzaldehyde

1-benzothiophen-3(2H)-one 1,1-dioxide

Downstream raw materials:

3-(2-cyanoethoxycarbonyl)-2-methyl-4-(3,4,5-trimethoxyphenyl)benzothieno[3,2-b]pyridine 5,5-dioxide