5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

Base Information

Chemical Name:5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole
CAS No.:128540-91-0
Molecular Formula:C₂₁H₂₂F₃N₃
Molecular Weight:373.421
Hs Code.:

Synonyms:5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

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Technology Process of 5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

There total 2 articles about 5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 128540-99-8
5-Cyano-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

: 128540-91-0
5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 16h; Ambient temperature;
DOI:10.1055/s-1990-26878

Reference yield:

: 128541-00-4
5-Fluoro-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

: 128540-91-0
5-Aminomethyl-1-(2,6-diethylphenyl)-2-phenyl-4-trifluoromethylimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / dibenzo-18-crown-6 / acetonitrile / Heating

2: 76 percent / LiAlH₄ / diethyl ether / 16 h / Ambient temperature

With lithium aluminium tetrahydride; dibenzo-18-crown-6; In diethyl ether; acetonitrile;
DOI:10.1055/s-1990-26878