(Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Base Information

• Chemical Name: (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione
• CAS No.: 628718-49-0
• Molecular Formula: C₄₀H₃₉BrN₂O₁₁S
• Molecular Weight: 835.726
• Mol file: 628718-49-0.mol

Synonyms:(Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Chemical Property of (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

There total 12 articles about (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

(Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-methoxymethoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione (628718-38-7) → (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione (628718-49-0)

Guidance literature:

With trifluoroacetic acid; at 25 ℃; for 1h;

DOI:10.1248/cpb.51.821

Reference yield:

2-bromo-5-hydroxy-4-methoxy-3-methylbenzaldehyde (287117-31-1) → (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione (628718-49-0)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 100 percent / K₂CO₃ / dimethylformamide / 1 h / 25 °C

2.1: 6.749 g / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 25 °C

3.1: 100 percent / H₂ / Rh/C / propan-2-ol / 19 h / 760 Torr

4.1: 4.106 g / pyridine; DMAP / 1 h / 25 °C

5.1: 72.9 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 2 h / 25 °C

6.1: NaH / dimethylformamide / 0 °C

6.2: dimethylformamide / 24 h / 25 °C

7.1: K₂CO₃ / methanol / 25 °C

8.1: 4.464 g / Et₃N; 4-DMAP / CH₂Cl₂ / 25 °C

9.1: 93.9 percent / TFA / 1 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; Rh on carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

DOI:10.1248/cpb.51.821

Reference yield:

2-bromo-4-methoxy-5-methoxymethoxy-3-methylbenzaldehyde (628718-95-6) → (Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-hydroxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione (628718-49-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 6.749 g / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / 25 °C

2.1: 100 percent / H₂ / Rh/C / propan-2-ol / 19 h / 760 Torr

3.1: 4.106 g / pyridine; DMAP / 1 h / 25 °C

4.1: 72.9 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 2 h / 25 °C

5.1: NaH / dimethylformamide / 0 °C

5.2: dimethylformamide / 24 h / 25 °C

6.1: K₂CO₃ / methanol / 25 °C

7.1: 4.464 g / Et₃N; 4-DMAP / CH₂Cl₂ / 25 °C

8.1: 93.9 percent / TFA / 1 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; Rh on carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;

DOI:10.1248/cpb.51.821

upstream raw materials:

(Z)-1-isopropyloxycarbonyl-6-(2-bromo-4-methoxy-5-methoxymethoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

p-toluenesulfonyl chloride

3-methyl-4,5-methylenedioxy salicylaldehyde

2-bromo-5-hydroxy-4-methoxy-3-methylbenzaldehyde

Downstream raw materials:

4-Benzyl-2-(2-bromo-5-hydroxy-4-methoxy-3-methyl-benzyl)-6-hydroxy-5-[1-[7-methyl-6-(toluene-4-sulfonyloxy)-benzo[1,3]dioxol-5-yl]-meth-(Z)-ylidene]-3-oxo-piperazine-1-carboxylic acid isopropyl ester