(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

Base Information

Chemical Name:(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one
CAS No.:1584730-47-1
Molecular Formula:C₃₄H₄₂O₃Si
Molecular Weight:526.791
Hs Code.:

Synonyms:(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

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Chemical Property of (12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

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Technology Process of (12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

There total 24 articles about (12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1584730-42-6
C₃₆H₄₆O₃Si

: 1584730-47-1
(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

Guidance literature:: With Grubbs catalayst; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 67.0%

: (S,Z)-(S)-pent-1-yn-3-yl 11-((tert-butyldiphenylsilyl) oxy) tridec-9-en-12-ynoate

: 1584730-47-1
(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

Guidance literature:: With copper(l) iodide; (triphenylphosphine)gold(I) chloride; iodine; N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 48h;
DOI:10.1002/ejoc.201800708

Reference yield:

: 1584730-42-6
C₃₆H₄₆O₃Si

: 1584730-53-9
C₃₄H₄₂O₃Si

: 1584730-47-1
(12S,17S,Z)-12-((tert-butyldiphenylsilyl)oxy)-17-ethyloxacycloheptadeca-10-en-13,15-diyn-2-one

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 43 ℃; for 12h; Reagent/catalyst; Solvent; Temperature; Overall yield = 93 %; Overall yield = 214 mg;
DOI:10.1021/ol500667d