(S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate

Base Information

• Chemical Name: (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate
• CAS No.: 1207604-27-0
• Molecular Formula: C₂₈H₂₅F₆NO₂
• Molecular Weight: 521.502
• Mol file: 1207604-27-0.mol

Synonyms:(S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate

Chemical Property of (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate

There total 2 articles about (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + 3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) → (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate (1207604-27-0)

Guidance literature:

With 2,7-bis[O⁽⁹⁾-allylhydrocinchonidinium-N-methyl]naphthalene dibromide; potassium hydroxide; In chloroform; water; toluene; at -20 ℃; for 84h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/jm9015685

Reference yield:

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + 3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) → (S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate (1207604-27-0) + C28H25F6NO2

Guidance literature:

With cesiumhydroxide monohydrate; C₆₃H₅₈NO⁽¹⁺⁾*Br^(1-); In toluene; at -50 ℃; for 15h; Overall yield = 91 percent; Overall yield = 80.6 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00535

Reference yield: 100.0%

(S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate (1207604-27-0) → (S)-tert-butyl 2-amino-3-(3,5-bis(trifluoromethyl)phenyl)propanoate (1207604-29-2)

Guidance literature:

(S)-tert-butyl 3-(3,5-bis(trifluoromethyl)phenyl)-2-(diphenylmethyleneamino)propanoate; With water; citric acid; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With potassium carbonate; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jm9015685

upstream raw materials:

N-(diphenylmethylene)glycine tert-butyl ester

3,5-bis(trifluoromethyl)benzyl bromide

Downstream raw materials:

(S)-tert-butyl 2-amino-3-(3,5-bis(trifluoromethyl)phenyl)propanoate