3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

Base Information

Chemical Name:3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid
CAS No.:1237535-97-5
Molecular Formula:C₁₆H₂₀F₃NO₄
Molecular Weight:347.334
Hs Code.:

Synonyms:3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

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Chemical Property of 3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

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Technology Process of 3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

There total 3 articles about 3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.2%

: 24424-99-5
di-tert-butyl dicarbonate

: 1237535-96-4
3-(1-amino-1-methylethyl)-5-(trifluoromethyl)benzoic acid

: 1237535-97-5
3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

Guidance literature:: di-tert-butyl dicarbonate; 3-(1-amino-1-methylethyl)-5-(trifluoromethyl)benzoic acid; With sodium hydroxide; In 1,4-dioxane;

With hydrogenchloride; water; In ethyl acetate; pH=1;

Reference yield:

: 1237535-95-3
3-[1-(acetylamino)-1-methylethyl]-5-(trifluoromethyl)benzoic acid

: 1237535-97-5
3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethylene glycol / 72 h / 150 °C

1.2: pH 5

2.1: sodium hydroxide / 1,4-dioxane

2.2: pH 1

With potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethylene glycol;
DOI:10.1021/jm101479y

Reference yield:

: 1274817-10-5
tert-butyl 3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)benzoate

: 1237535-97-5
3-(1-[(tert-butoxycarbonyl)amino]-1-methylethyl)-5-(trifluoromethyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 3 h / 20 °C

1.3: pH 1

2.1: potassium hydroxide / ethylene glycol / 72 h / 150 °C

2.2: pH 5

3.1: sodium hydroxide / 1,4-dioxane

3.2: pH 1

With sulfuric acid; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethylene glycol;
DOI:10.1021/jm101479y