(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

Base Information

Chemical Name:(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine
CAS No.:1350803-24-5
Molecular Formula:C₁₄H₁₈O₃
Molecular Weight:234.295
Hs Code.:

Synonyms:(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

Suppliers and Price of (2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

There total 4 articles about (2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1350803-12-1
(S)-1-((2R,4R)-6-methoxy-4,7-dimethylchroman-2-yl)ethanol

: 1350803-24-5
(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

: 1350803-26-7
2-((2R,4R,5S)-4,5-dihydroxyhexan-2-yl)-5-methylcyclohexa-2,5-diene-1,4-dione

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 60 ℃; for 0.166667h;
DOI:10.1021/jo201971g

Reference yield:

: 1350803-11-0
(2R,2'S,4R,5'S)-6-methoxy-4,5',7-trimethyl-2'-phenethylspiro[chroman-2,4'-[1,3]dioxolane]

: 1350803-24-5
(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

: 1350803-26-7
2-((2R,4R,5S)-4,5-dihydroxyhexan-2-yl)-5-methylcyclohexa-2,5-diene-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / water; acetonitrile / 0.17 h / 60 °C

With triethylsilane; ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; In dichloromethane; water; acetonitrile;
DOI:10.1021/jo201971g

Reference yield:

: 1350803-05-2
tert-butyl (2-formyl-4-methoxy-5-methylphenyl) carbonate

: 1350803-24-5
(2R,3S,5R)-7-methoxy-3,5,8-trimethyl-3,5-dihydro-2H-2,5-methanobenzo[e][1,4]dioxepine

: 1350803-26-7
2-((2R,4R,5S)-4,5-dihydroxyhexan-2-yl)-5-methylcyclohexa-2,5-diene-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 3 h / -78 - 20 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

3: ammonium cerium (IV) nitrate / water; acetonitrile / 0.17 h / 60 °C

With triethylsilane; ammonium cerium (IV) nitrate; boron trifluoride diethyl etherate; In diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jo201971g