3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 218594-01-5
• Molecular Formula: C10H17 N O4
• Molecular Weight: 229.27
• Hs Code.: 2934999090
• Mol file: 218594-01-5.mol

Synonyms:3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property of 3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.462
• Boiling Point: 330ºC at 760 mmHg
• Flash Point: 153.4ºC
• PSA: 55.84000
• Density: 1.088g/cm3
• LogP: 1.14920
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-3-Formyl-morpholine-4-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-3-Formyl-morpholine-4-carboxylic Acid tert-Butyl Ester is used in preparation of dihydrobenzodioxine derivatives and analogs as RAS-effector protein interaction inhibitors.

Technology Process of 3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 3 articles about 3-(2-OXO-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(R)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester (215917-99-0) → (S)-3-formylmorpholin-4-carboxylic acid tert-butyl ester (218594-01-5,1257850-86-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.7b00083

Reference yield:

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid (783350-37-8) → (S)-3-formylmorpholin-4-carboxylic acid tert-butyl ester (218594-01-5,1257850-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 16 h / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 16 h / 0 - 20 °C

With borane-THF; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

Reference yield:

→ (S)-3-formylmorpholin-4-carboxylic acid tert-butyl ester (218594-01-5,1257850-86-4)

Guidance literature:

upstream raw materials:

(R)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid

Refernces

• 1、 -. "DIHYDROPYRIMIDINYLTHIAZOLE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 28. . Retrieved 2019/07/17.
• 2、 -. "PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF". Paragraph 00121. . Retrieved 2015/06/11.