N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

Base Information

Chemical Name:N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide
CAS No.:1332881-53-4
Molecular Formula:C₁₉H₁₅N₃O₃S
Molecular Weight:365.412
Hs Code.:

Synonyms:N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

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Chemical Property of N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

Chemical Property:

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Technology Process of N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

There total 5 articles about N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1135797-91-9
(2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone

: 1000-70-0
bis(trimethylsilyl)carbodi-imide

: 1332881-53-4
N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

: 1311195-67-1
N-((2-phenylthiazol-4-yl)(3,4,5-trimethoxyphenyl)methylene)cyanamide

Guidance literature:: (2-phenylthiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.5h;

bis(trimethylsilyl)carbodi-imide; In dichloromethane; Inert atmosphere;

With water; In dichloromethane; Cooling with ice;

Reference yield:

: 62096-93-9,116179-34-1,19983-15-4
2-phenyl-4,5-dihydrothiazole-4-carboxylic acid

: 1332881-53-4
N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

: 1311195-67-1
N-((2-phenylthiazol-4-yl)(3,4,5-trimethoxyphenyl)methylene)cyanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

3.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: titanium tetrachloride / dichloromethane / 0.5 h / 0 °C

4.2: Inert atmosphere

4.3: Cooling with ice

With 4-methyl-morpholine; Bromotrichloromethane; titanium tetrachloride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1001669-22-2
2-phenylthiazole-4-carboxylic acid N-(methoxy)methylamide

: 1332881-53-4
N-((4-hydroxy-3,5-dimethoxyphenyl)(2-phenylthiazol-4-yl)methylene)cyanamide

: 1311195-67-1
N-((2-phenylthiazol-4-yl)(3,4,5-trimethoxyphenyl)methylene)cyanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 0.5 h / 0 °C

2.2: Inert atmosphere

2.3: Cooling with ice

With titanium tetrachloride; In tetrahydrofuran; dichloromethane;