(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

Base Information

Chemical Name:(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole
CAS No.:1374351-11-7
Molecular Formula:C₂₇H₂₆FN₇O
Molecular Weight:483.548
Hs Code.:

Synonyms:(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

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Chemical Property of (R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

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Technology Process of (R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

There total 8 articles about (R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-5-(5-(piperidin-3-yI)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole trifluoroacetate

: 146137-74-8
2-fluoro-6-methoxybenzaldehyde

: 1374351-11-7
(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 395101-67-4
3-bromo-1H-indazole-5-carbonitrile

: 1374351-11-7
(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 0 - 20 °C

2.1: methanol / 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

5.1: triethylsilane / dichloromethane / 20 °C

6.1: sodium tris(acetoxy)borohydride / methanol / 0.5 h / 20 °C

With hydrogenchloride; triethylsilane; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 194726-40-4
(3R)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 1374351-11-7
(R)-5-(5-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-1,2,4-triazol-3-yl)-3-(pyridin-4-yl)-1H-indazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine / methanol / 3 h / 100 °C / Microwave irradiation

2.1: methanol / 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

5.1: triethylsilane / dichloromethane / 20 °C

6.1: sodium tris(acetoxy)borohydride / methanol / 0.5 h / 20 °C

With triethylsilane; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; hydrazine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;