2-Chloro-4,6-dihydroxy-3-phenylpyridine

Base Information

• Chemical Name: 2-Chloro-4,6-dihydroxy-3-phenylpyridine
• CAS No.: 32265-03-5
• Molecular Formula: C11H8 Cl N O2
• Molecular Weight: 221.643
• Hs Code.: 2933399090
• Mol file: 32265-03-5.mol

Synonyms:2(1H)-Pyridone,6-chloro-4-hydroxy-5-phenyl- (8CI); 2,4-Pyridinediol, 6-chloro-5-phenyl- (7CI);2-Chloro-4,6-dihydroxy-3-phenylpyridine;6-Chloro-4-hydroxy-5-phenyl-1H-pyridin-2-one

Chemical Property of 2-Chloro-4,6-dihydroxy-3-phenylpyridine

Chemical Property:

• Boiling Point: 361.6±42.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 53.35000
• Density: 1.44±0.1 g/cm3(Predicted)
• LogP: 2.81320

Purity/Quality:

97% ^*data from raw suppliers

6-CHLORO-5-PHENYL-2,4-PYRIDINEDIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4,6-dihydroxy-3-phenylpyridine

There total 1 articles about 2-Chloro-4,6-dihydroxy-3-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

phenylacetonitrile (140-29-4) + malonoyl dichloride (1663-67-8) → 6-chloro-4-hydroxy-5-phenyl(1H)-pyridin-2-one (32265-03-5)

Guidance literature:

at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.025

Reference yield: 98.0%

6-chloro-4-hydroxy-5-phenyl(1H)-pyridin-2-one (32265-03-5) → 4-hydroxy-5-phenylpyridin-2(1H)-one (102249-52-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 60 ℃; for 40h;

DOI:10.1021/jo952053i

Reference yield: 93.0%

6-chloro-4-hydroxy-5-phenyl(1H)-pyridin-2-one (32265-03-5) + 3,3-dimethyl acrylaldehyde (107-86-8) → 7-chloro-2,2-dimethyl-8-phenyl-2,6-dihydro-5H-pyrano[3,2-c]pyridin-5-one

Guidance literature:

With triethylamine; In ethanol; for 12h; Reflux;

DOI:10.1016/j.bmcl.2021.127845

upstream raw materials:

phenylacetonitrile

malonoyl dichloride

Downstream raw materials:

6-chloro-4-hydroxy-1-methyl-5-phenyl-2(1H)-pyridone

4-hydroxy-5-phenylpyridin-2(1H)-one

6-Chloro-4-hydroxy-3-nitro-5-phenyl-1H-pyridin-2-one

6-chloro-4-hydroxy-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbaldehyde