(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Base Information

Chemical Name:(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
CAS No.:1616339-82-2
Molecular Formula:C₂₁H₂₀FN₃O₅
Molecular Weight:413.405
Hs Code.:

Synonyms:(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Suppliers and Price of (2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Chemical Property:

Purity/Quality:: HPLC ≥ 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

There total 3 articles about (2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616340-76-1
C₁₅H₁₆N₂O₆

: 140-75-0
para-fluorobenzylamine

: 1616339-82-2
(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: C₁₅H₁₆N₂O₆; para-fluorobenzylamine; With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; for 0.5h;

With magnesium bromide; In acetonitrile; at 50 ℃; for 0.166667h;

Reference yield:

: 1616340-75-0
1-(2,2-dihydroxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

: 1616339-82-2
(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 16 h / 20 - 85 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 0.5 h

2.2: 0.17 h / 50 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile;

Reference yield:

: 1335210-23-5
1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

: 1616339-82-2
(2S,5R,13aS)-N-(4-fluorobenzyl)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonic acid; acetic acid / acetonitrile / 81 h / -10 - 75 °C

2.1: potassium carbonate / acetonitrile / 16 h / 20 - 85 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 0.5 h

3.2: 0.17 h / 50 °C

With methanesulfonic acid; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile;