(1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine

Base Information

Chemical Name:(1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine
CAS No.:218151-57-6
Molecular Formula:C₉H₁₂N₂
Molecular Weight:148.208
Hs Code.:
DSSTox Substance ID:DTXSID001272246
Nikkaji Number:J323.243C
Mol file:218151-57-6.mol

Synonyms:(1R,2S)-2,3-DIHYDRO-1H-INDENE-1,2-DIAMINE;218151-57-6;57432-87-8;rel-(1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine;1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2S)-(9CI);1beta,2beta-Indanediamine;SCHEMBL3196912;DTXSID001272246;CS-0120950;1H-indene-1,2-diamine, 2,3-dihydro-, (1R,2S)-rel-

Suppliers and Price of (1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine

Chemical Property:

Boiling Point:266℃
Flash Point:134℃
PSA：52.04000
Density:1.108
LogP:1.97040
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:148.100048391
Heavy Atom Count:11
Complexity:147

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C2=CC=CC=C21)N)N
Isomeric SMILES:C1[C@@H]([C@@H](C2=CC=CC=C21)N)N

Technology Process of (1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine

There total 5 articles about (1R,2S)-2,3-Dihydro-1H-indene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218151-62-3
(1R,2S)-(-)-cis-1,2-diazidoindane

: 218151-57-6
(1R,2S)-Indan-1,2-diamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 12h; Ambient temperature;
DOI:10.1016/S0957-4166(98)00330-9

Reference yield:

: 180980-12-5
(1R,2R)-(-)-trans-1-azidoindan-2-ol

: 218151-57-6
(1R,2S)-Indan-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 3 h

2: NaN₃ / dimethylformamide / 3 h / 60 °C

3: H₂ / 10percent Pd/C / ethanol / 12 h / Ambient temperature

With sodium azide; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(98)00330-9

Reference yield:

: trans-(1RS,2RS)-1-azido-2,3-dihydro-1H-inden-2-ol

: 218151-57-6
(1R,2S)-Indan-1,2-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 44 percent / lipase 237.87 / hexane; diethyl ether / 3 h / 40 °C

2: 100 percent / MeONa / methanol / 0.5 h

3: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 3 h

4: NaN₃ / dimethylformamide / 3 h / 60 °C

5: H₂ / 10percent Pd/C / ethanol / 12 h / Ambient temperature

With sodium azide; lipase 237.87; hydrogen; sodium methylate; sodium hydride; palladium on activated charcoal; In methanol; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(98)00330-9