2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol

Base Information

• Chemical Name: 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol
• CAS No.: 884324-39-4
• Molecular Formula: C₂₈H₂₅N₃O₃
• Molecular Weight: 451.525
• Mol file: 884324-39-4.mol

Synonyms:2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol

Chemical Property of 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol

There total 5 articles about 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol → 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol (884324-39-4)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2006.01.135

Reference yield:

(6,6,8,8-tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol (884324-37-2) → 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol (884324-39-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / pyridine / 4.5 h / 20 °C

2: tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

3: SOCl₂; Et₃N / benzene / 2.5 h / 20 °C

4: NaN₃ / dimethylformamide / 20 °C

With pyridine; thionyl chloride; sodium azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.tetlet.2006.01.135

Reference yield:

2-hydroxymethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol → 2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenol (884324-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; Et₃N / benzene / 2.5 h / 20 °C

2: NaN₃ / dimethylformamide / 20 °C

With thionyl chloride; sodium azide; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.tetlet.2006.01.135

upstream raw materials:

(6,6,8,8-tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol

6,6,8,8-tetraisopropyl-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-10H-5,7,9-trioxa-6,8-disila-benzocyclooctene

2,4-bis(hydroxymethyl)phenol

Downstream raw materials:

pentanedioic acid mono-{2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenyl} ester