3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Base Information

Chemical Name:3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone
CAS No.:245076-30-6
Molecular Formula:C₃₅H₅₀O₄SSi
Molecular Weight:594.931
Hs Code.:

Synonyms:3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

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Chemical Property of 3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

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Technology Process of 3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

There total 8 articles about 3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 976-71-6
canrenone

: 245076-35-1
4-(t-butyldimethylsilyloxy)-benzyl mercaptan

: 245076-30-6
3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Guidance literature:: With sodium; at 45 ℃; for 0.75h;
DOI:10.1016/S0968-0896(98)00260-0

Reference yield: 71.0%

: 38753-76-3
3-(3-oxo-7α-thio-17β-hydroxy-4-androsten-17α-yl)propionic acid γ-lactone

: 120506-39-0
(4-(bromomethyl)phenoxy) (tert-butyl) dimethylsilane

: 245076-30-6
3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 2h;
DOI:10.1016/j.steroids.2012.09.005

Reference yield:

: 52-01-7
SPIRONOLACTONE

: 245076-30-6
3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / sodium methoxide / tetrahydrofuran / 18 h / 20 °C

2: 91 percent / sodium / 0.75 h / 45 °C

With sodium methylate; sodium; In tetrahydrofuran; 1: Elimination / 2: Addition;
DOI:10.1016/S0968-0896(98)00260-0