(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Base Information

Chemical Name:(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane
CAS No.:636596-53-7
Molecular Formula:C₃₁H₅₆O₄Si
Molecular Weight:520.869
Hs Code.:

Synonyms:(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Suppliers and Price of (4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

There total 7 articles about (4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 929915-17-3
(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxy-1'-hexadecynyl]-2-phenyl-1,3-dioxolane

: 636596-53-7
(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2.5h;
DOI:10.1021/ol026393j DOI:10.1002/chem.200305185

Reference yield:

: 153062-86-3
(R)-tetradecane-1,2-diol

: 636596-53-7
(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / CH₂Cl₂ / 0 - 20 °C

2.1: imidazole / dimethylformamide / 0 - 20 °C

3.1: DIBAL-H / CH₂Cl₂ / -78 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 20 °C

5.1: CSA / tetrahydrofuran / Heating

5.2: 96 percent / (1R,2S)-N-methylephedrine; Zn(OTf)2; Et₃N / toluene / 20 °C

6.1: 100 percent / H₂; Et₃N / Pd/C / ethyl acetate / 2.5 h / 20 °C

With pyridine; 1H-imidazole; camphor-10-sulfonic acid; hydrogen; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol026393j

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 636596-53-7
(4S)-4-[(3'R,4'R)-4'-(tert-butyldimethylsilyloxy)-3'-hydroxyoctadecanyl]-2-phenyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1.1: CSA / tetrahydrofuran / Heating

1.2: 96 percent / (1R,2S)-N-methylephedrine; Zn(OTf)2; Et₃N / toluene / 20 °C

2.1: 100 percent / H₂; Et₃N / Pd/C / ethyl acetate / 2.5 h / 20 °C

With camphor-10-sulfonic acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ol026393j