3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)

Base Information

Chemical Name:3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)
CAS No.:217447-50-2
Molecular Formula:C₆H₁₀N₂O₃
Molecular Weight:158.157
Hs Code.:
Mol file:217447-50-2.mol

Synonyms:3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)

Suppliers and Price of 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI)

There total 9 articles about 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-4-hydroxy-,methylester,(3R,4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 217447-41-1
methyl 5,5-dimethoxy-3-oxo-4-pentanoate

: 217447-50-2
(3R,4R)-4-Hydroxy-2,3,4,5-tetrahydro-pyridazine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / H₂ / (R)-BinapRuBr₂ / methanol / 18 h / Ambient temperature

2: 1.) MeZnBr, 2.) LDA / 1.) THF, 0 deg C, 1 h, 2.) THF, -78 deg C, 1 h; -78 deg C, 2.5 h

3: 1.) H₂, 2.) TFA / 1.) Pd/C / 1.) MeOH, r.t., 0.5 h, 2.) MeOH, H₂O

With hydrogen; trifluoroacetic acid; lithium diisopropyl amide; zinc methyl bromide; palladium on activated charcoal; [(R)-BINAP]RuBr₂; In methanol;
DOI:10.1055/s-1998-1921

Reference yield:

: 171514-06-0
methyl (3S,4S)-4-(O-t-butyldimethylsilyl)hydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylate

: 217447-50-2
(3S,4S)-4-Hydroxy-2,3,4,5-tetrahydro-pyridazine-3-carboxylic acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/0957-4166(95)00258-Q

Reference yield:

: 217447-49-9
Methyl (2R,3R)-5,5-dimethoxy-2-[N,N'-(dibenzylcarbonylhydrazino)]-3-hydroxypentanoate

: 217447-50-2
(3R,4R)-4-Hydroxy-2,3,4,5-tetrahydro-pyridazine-3-carboxylic acid methyl ester

Guidance literature:: With hydrogen; trifluoroacetic acid; palladium on activated charcoal; Yield given. Multistep reaction; 1.) MeOH, r.t., 0.5 h, 2.) MeOH, H₂O;
DOI:10.1055/s-1998-1921